by
C.-H. HeldinC.-H. Heldin
This volume provides a compendium of recent findings of basic concepts of TGF-beta signaling in normal physiology and cancer pathobiology. Details of various aspects of TGF-beta in cancer treatments in cells and tissues are provided.
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Transforming Growth Factor-ß in Cancer Therapy
Volume 2: Cancer Treatment and Therapy
Sonia B. Jakowlew, Ph.D., Editor
The Humana Press, Inc., Publisher
TABLE OF CONTENTS
In Memorium for Anita B. Roberts, PhD
John M. McPherson*
Preface
Sonia B. Jakowlew*
Foreward
Carl-Henrick Heldin*
Contributors
Part I. Transforming Growth Factor-ß in Developing and Advanced Cancers
1 Transforming Growth Factor-ß Signaling in Pancreas Development and
Pancreatic Cancer
Sushil Rane*, Huei-Min Lin, Ji-Hyeon Lee, and Wan Jiao
2 Role of Transforming Growth Factor-ß (TGF-ß) in the Pathogenesis of
Head and Neck Squamous Cell
Carcinoma (HNSCC)
Stephen M. Weber, Shi-Long Lu, Sophia Bernstein, and Xiao-Jing Wang*
3 TGF-ß, Smads and Cervical Cancer
Devarajan Karunagaran* and Goodwin Jinesh
4 TGF-ß Signaling and Biglycan in Pancreatic Cancer
Hendrik Ungefroren*
5 TGF-ß Signaling in Endometrial Cancer
Dagmara Piestrzeniewicz-Ulanska*, David H. McGuinnes, and Grant R.
Yeaman
6 TGF-ß Ligands, TGF-ß Receptors, and Lung Cancer
Guiying Wang, Rongmei Zhang, Xiaohua Hu, Jiucun Wang, Lindsey J. Leach,
and Zewei Luo*
7 Role of TGF-ß in Osteolytic Bone Metastases
Laurent Bartholin* and Thesesa A. Guise
8 Hormonal Regulation of Transforming Growth Factor-beta in Breast
Cancer
Miriam Buck* and Cornelius Knabbe
9 TGF-ß Signaling in Esophageal Cancer
Minoru Fukuchi*, Hiroyuki Kato, and Hiroyuki Kuwano
10 TGF-beta and HER2/ErbB2 and Breast Cancer Progression
Natasa Todorovic-Rakovic*
11 TGF-beta dependent T Cell Regulation in Colitis and Colon Cancer
Christoph Becker* and Markus F. Neurath
12 Role of Transforming Growth Factor-beta in the Kidney – Physiology and Pathology
Elena Gagliardini and Ariela Benigni*
13 Perturbations of TGF-ß Signaling in Leukocytes as Driversof
Leukemogenesis and Epithelial
Tumorigenesis
Lawrence A. Wolfraim* and John J. Letterio
14 Transforming Growth Factor-ß in Brain Functions and Dysfunctions
Denis Vivien*, Karim Benchenane, and Carine Ali
15 Inhibition of TGF-ß Signaling in Multiple Myeloma and it’s Bone
Marrow Environment
Hiroshi Yasui, Teru Hideshima, and Kenneth C. Anderson*
16 Key Roles of Smad3 in TGF-ß Responses in the Prostate
Kyung Song and David Danielpour*
17 Smad Signaling in Leukemic Growth and Differentiation: Crosstalk
Between Smad and Multiple
Pathways Through Activation of the TGF-ß Type I Receptor
Francis W. Ruscetti*, Salem Akel, Maria Birchenall-Roberts, Zhouhong
Cao, and Anita Roberts
Part II. Transforming Growth Factor-ß in Cancer Treatment and Therapy
18 High Throughput Screening of Protein Interaction Networks in the
TGFß Interactome: Understanding the
Signaling Mechanisms Driving Tumor Progression
Miriam Barrios-Rodiles, Alicia Viloria-Petit, Kevin R. Brown, Igor
Jurisica, and Jeffrey L.
Wrana*
19 Tumor Suppressor and Pro-Progression Roles for TGF-ß in Breast Cancer
Ethan Kohn* and Binwu Tang
20 Tumor Suppressors p53 and TGF-ß Converge to Regulate the
Alpha-fetoprotein – Oncodevelopmental
Tumor Marker
Deepti S. Wilkinson and Michelle Craig Barton*
21 TGF-ß1: Roles in DNA Damage Responses
Kumari L. Andarawewa, Julie Kirshner, Joni D. Mott, and Mary Helen
Barcellos-Hoff*
22 The Rationale For and Effects of Targeting TGF-beta for Glioma
Therapy
Anita B. Hjelmeland* and Jeremy N. Rich
23 Tumor Suppressor Function of TGF-ß1 in T Cells
Ramireddy Bommireddy* and Thomas Doetschman
24 Therapeutic Effects of Adenovirus-mediated Gene Transfer of TGF-ß Signal Antagonists on Undesirable
Epithelial-mesenchymal Transition and Neovascularization
Shizuka Saika*
25 Role of TGF-ß in Tumor Protection
| ISBN-13: | 9781588297150 | |
| Publisher: | Springer-Verlag New York, LLC | |
| Publication date: | 03/28/2008 | |
| Series: | Cancer Drug Discovery and Development Series | |
| Edition description: | 2008 | |
| Pages: | 786 | |
| Product dimensions: | 7.00(w) x 10.10(h) x 1.40(d) |
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