Views: 56

The Dentate Gyrus: Structure, Functions and Health Implications

Product code : 1634980781

BY Feng-Ru Tang, PhD, MD (Editor) – Singapore Nuclear Research and Safety Initiative, National University of Singapore, Singapore


    The Dentate Gyrus: Structure, Functions and Health Implications

    BY Feng-Ru Tang, PhD, MD (Editor) – Singapore Nuclear Research and Safety Initiative, National University of Singapore, Singapore

    The dentate gyrus (DG) is one of the most sensitive regions to various brain insults due to the occurrence of neurogenesis in its subgranular zone. Thus, it may serve as a brain sensor to radiation exposure, chemical and biological toxins, alcohol abuse, smoking, drug treatments, hormone imbalances, stress, pain, hypoxia, brain trauma, malnutrition and aging. DG is also involved in the pathogenesis of multiple neurological and neuropsychological disorders including intractable temporal lobe epilepsy (TLE), Alzheimer’s disease (AD), major depressive disorder (MDD), post-traumatic stress disorder (PTSD), and schizophrenia.

    Over decades of research, our understanding regarding the function and physiology of the DG is ever-changing. While it is commonly believed that the dentate granule cells are primarily responsible for executing higher brain functions such as learning and memory, there is increasing evidence demonstrating that the glial cells, particularly microglia, astrocytes and oligodendrocytes, are also involved in memory formation. Therefore, a book that systematically reviews DG structure, function and health implications is needed to update clinicians and researchers with state-of-the-art knowledge.

    In the first three chapters of this book, the recent progresses in the study of DG development with relevant molecular mechanisms, the cytoarchitectonics of DG with laminar and sublaminar distribution of different types of neurons and glial cells, as well as afferent and efferent of the DG and their neurophysiological roles will be described respectively. In Chapters 4 and 5, DG as a brain sensor to radiation exposure, and pre- and post-natal radiation-induced DG damage and cognitive impairment will be reviewed accordingly. The involvement of DG in pathogenesis of neurological disorders including TLE and AD will be discussed in Chapters 6 and 7. Finally, in the last two chapters, i.e., Chapters 8 and 9, the roles of DG in the development of neuropsychological disorders including MDD, PTSD and schizophrenia will be presented.


    Publication Date: October 12, 2021
    Status: Available

    Pages: 359

Related Products


Haschek and Rousseaux's Handbook of Toxicologic Pathology: Volume 1: Principles and Practice of Toxicologic Pathology 4th Edition

by Wanda M. Haschek (Editor), Colin G. Rousseaux (Editor), Matthew A. Wallig (Editor), Brad Bolon (Editor)


Nutrition: Enseignement intégré - UE Nutrition (French Edition)

by Collège des Enseignants de Nutrition (Author)


Introduction to Radiologic Technology 8th Edition

by William J. Callaway MA RT(R) (Author)


Community Public Health in Policy and Practice 3rd Edition

by Sarah Cowley BA PhD PGDE RGN RHV HVT (Editor), Karen Whittaker PhD MSc PGCert BN(Hons) (Editor)


Pathology for the Health Professions 6th Edition

By Ivan Damjanov, Anamarija Morovic Perry, Kyle Perry


A Textbook of Children's and Young People's Nursing 3rd Edition

by Edward Alan Glasper PhD BA RSCN RGN ONC DN CertEd RNT (Author), James Richardson PhD BA RGN RSCN PGCE (Author), Dr Duncan Randall RGN RSCN RHV RNT NP BSc(HONS) Pg Cert PhD (Author)


Darby’s Comprehensive Review of Dental Hygiene 9th Edition

by Christine M Blue BSDH MS (Author)


Fundamental Concepts and Skills for Nursing, 6e 6th Edition

by Patricia A. Williams RN MSN CCRN (Author)


Clinical Nursing Skills and Techniques 10th Edition

by Sandra Luz Martinez de Castillo EdD RN (Author)


Mosby's Drug Guide for Nursing Students with 2022 Update 14th Edition

by Linda Skidmore-Roth RN MSN NP (Author)


Aromatherapy for Health Professionals Revised Reprint 5th Edition

By Shirley Price Cert Ed FISPA MIFA FIAM, Len Price Cert Ed MIT(Trichology) FISPA FIAM, Penny Price


Ebersole and Hess' Gerontological Nursing & Healthy Aging 6th Edition

by Theris A. Touhy DNP CNS DPNAP (Author), Kathleen F Jett PhD GNP-BC DPNAP (Author)


Drug Discovery and Development: Technology in Transition 3rd Edition

by Raymond G Hill (Editor), Duncan Richards (Editor)


Leadership and Nursing Care Management, 7e 7th Edition

by Diane Huber PhD RN NEA-BC FAAN (Author), M. Lindell Joseph PhD RN FAONL FAAN (Author)


Lavin's Radiography for Veterinary Technicians 7th Edition

by Marg Brown RVT BEd Ad Ed (Author), Lois Brown RTR (Cdn/USA) ACR MSc (Author)