Sample Sizes for Clinical Trials, 2nd Edition (PDF)

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Format : Publisher PDF

File Size : 56.9 MB

The book “Sample Sizes for Clinical Trials, Second Edition” by Steven A. Julious is a practical guide that helps researchers estimate the appropriate sample size for their clinical trials. It covers various types of data and trial objectives, with real-life examples. The new edition includes revisions and new chapters on multiplicity, cluster trials, pilot studies, and single arm trials. The book is aimed at researchers and practitioners in clinical trials and biostatistics and can be used to teach a course on sample size calculations. The eBook has 420 pages and was published on June 21, 2023, by Chapman and Hall/CRC.

Category: MEDICAL BOOK

Description

Sample Sizes for Clinical Trials, 2nd Edition

About the Book

Sample Sizes for Clinical Trials, Second Edition by Steven A. Julious is a practical guide that facilitates researchers in estimating the sample size for clinical trials. The book gives a comprehensive coverage of sample size calculations, which includes Normal, binary, ordinal, and survival outcome data. In addition to this, it covers superiority, equivalence, non-inferiority, bioequivalence, and precision objectives for both parallel group and crossover designs. It is equipped with detailed worked examples to illustrate how to do the calculations and present them in protocols. The book also highlights some of the pitfalls in calculation and the key steps leading to the final sample size calculation.

The second edition of this book has been revised, with some chapters being substantially revised, while four new chapters have been added on multiplicity, cluster trials, pilot studies, and single arm trials. The book is primarily aimed at researchers and practitioners of clinical trials and biostatistics, and it could be used to teach a course on sample size calculations.

Features

Covers all aspects of sample size calculations in clinical trials
Highlights how trial objectives impact the study design
Provides real-life clinical trial examples demonstrating the application of calculations
Extended second edition with new chapters added

The importance of a sample size calculation when designing a clinical trial is emphasized in the book. With tables to assist in the calculations and an associated worked example, it enables readers to quickly find an appropriate sample size formula. This book is published by Chapman and Hall/CRC and is available in digital format with 420 pages.