9780387351346

Alzheimer’s Disease: Advances in Genetics, Molecular and Cellular Biology (PDF)

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Alzheimer’s Disease: Advances in Genetics, Molecular and Cellular Biology (PDF)

9780387351346 1

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by
Sangram S. SisodiaSangram S. Sisodia

This book examines every major aspect of Alzheimer disease clinical, epidemiologic, structural, chemical, genetic, molecular, and therapeutic. This edition includes expanded coverage of the cellular-level exploration of related dementing disorders, with in-depth presentation of prion diseases, Pick’s disease, fronto-temporal disorders, transgenic models, and biochemistry of presenilins. Treatment of symptoms with therapeutic drugs is discussed, along with outcomes of and problems inherent in clinical trials for AD. The broad coverage of AD in this book benefits clinicians, educators, investigators, and health administrators.

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Product Details

ISBN-13:
9780387351346
Publisher:
Springer US
Publication date:
12/28/2006
Edition description:
2007
Pages:
286
Product dimensions:
5.98(w) x 9.02(h) x 0.03(d)

Table of Contents

Introduction     vii
The Genetics of Alzheimer’s Disease   Lars Bertram     1
APP Biology, Processing and Function   Gopal Thinakaran   Edward H. Koo     17
The Biology of the Presenilin Complexes   Tomoko Wakabayashi   Takeshi Iwatsubo   Bart De Strooper     35[Beta]-secretase: Physiological Role and Target Validation   Fiona M. Laird   Mohamed H. Farah   Hey-Kyoung Lee   Alena V. Savonenko   Donald L. Price   Philip C. Wong     59
Cognitive Impairment in Transgenic A[Beta] and Tau Models of Alzheimer’s Disease   Karen H. Ashe     77
Cholesterol and [Beta]-Amyloid   Henri J. Huttunen   Dora M. Kovacs     93
A[Beta] Structure and Aggregation   Charles Glabe   Ashley I. Bush     113
Signaling Mechanisms that Mediate A[Beta] Induced Neuronal Dysfunction   Carl W. Cotman   Jorge Busciglio     133
Beta Amyloid and Excitatory Synapses   Roberto Malinow   Helen Hsieh   Wei Wei     151
A[Beta] Degradation   Malcolm Leissring   Takaomi C. Saido     157
Role of A[Beta] Transport and Clearance in the Pathogenesis and Treatment of Alzheimer’sDisease   David M. Holtzman   Berislav Zlokovic     179
Tau Gene Mutations in FTDP-17 Syndromes   Matthew J. Winton   John Q. Trojanowski   Virginia M-Y. Lee     199
Animal Models of Tauopathy   Karen Duff   Pavan Krishnamurthy   Emmanuel Planel   Michael Hutton     215
Tau and Axonal Transport   E.-M. Mandelkow   E. Thies   E. Mandelkow     237
Growth Factors in Alzheimer’s Disease   A. H. Nagahara   M. H. Tuszynski     251
Index     279

Product Details

ISBN-13: 9780387351346
Publisher: Springer US
Publication date: 12/28/2006
Edition description: 2007
Pages: 286
Product dimensions: 5.98(w) x 9.02(h) x 0.03(d)

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