TMM publishes articles that cover new concepts in mechanisms of human biology and pathology, with direct implications for diagnostics and therapy. The reviews bridge the gap between laboratory research and clinical applications, discussing not only preclinical studies but also research conducted on patient samples, first-in-man studies, and patient-enrolled trials. By exploring the interface between bench and bedside, the articles in TMM contribute to our understanding of human health and disease.

The major themes covered in TMM include disease mechanisms, tools and technologies, diagnostics, and therapeutics. The journal particularly seeks articles that are relevant to more than one of these themes. By encouraging multidisciplinary approaches, TMM aims to facilitate discussions, push the boundaries of traditional clinical or scientific categorization, and foster new connections between scientists and clinicians.

TMM serves as a platform for discussions that go beyond the scope of traditional clinical or scientific research, inspiring new directions of study in molecular medicine. The reviews and opinions published in the journal provide templates for future explorations and offer insights that can contribute to the advancement of human health.

In addition to scientific content, TMM recognizes the vital societal element of medicine. Molecular interventions raise ethical, legal, and financial issues, and the journal also publishes discussions on topics such as the clinical trial landscape, science policy, and medical ethics.

Building on 25 years of experience in publishing the Trends journals, TMM aims to deliver articles that are both provocative and authoritative while remaining accessible to a broad audience. The journal seeks to provide a platform for researchers, clinicians, and policymakers to engage in meaningful discussions and work collaboratively towards improving human health.